3/1/2023 0 Comments Boots of the long road![]() ![]() The North Face VECTIV Exploris Mid offers excellent protection from track hindrances and hurdles. So much so that the boots were ideal when negotiating my sandy and sometimes sludgy rambling, from slippery rocks to boggy sand. The Surface Control rubber outsoles bite into loose and rocky terrain and the 4mm lugs provided excellent grip or stickiness, even in the rocky and sandy conditions that we encountered in Bouddi NP. While comfort is always paramount on the trail, traction comes a close second and happily, it’s one of the VECTIV Exploris’ strengths. ![]() ![]() The curved sole of the boot is a case of function over fashion. And it works I was just as fresh-footed at the 10km mark on my day’s hike as I was at the outset. The idea and science behind this is to encourage a rolling, forward motion and in turn maximise and maintain energy transfer. Also, the criss-cross and cross-ankle lacing system (aka Ghillie), padded tongue and mesh collar with moulded details hold my foot securely (I’m prone to an ankle roll, so this is something I always look for in a boot) without any pressure points.įor me, the boot’s most distinctive physical feature is its shape – it curves up at the toes. Together they make for a comfy and supportive stride and keep my feet safe from rocks, sticks and any spikey vegetation on the track. Slip your foot inside the shoe and the interior is plush with a nicely padded midsole, What makes it so? The hard-working OrthoLite footbed combined with a high-rebound, single-density EVA midsole (a man-made material that is considered foam). Weighing in at just 346 grams per shoe (women’s size 8) and with a slew of trail-running inspired features, The North Face VECTIV Exploris Mid is inarguably an ultra-modern take on a hiking boot. The rockered profile can feel odd when you first pull on these boots (I have a pair of the trail runners and full disclosure, am a fan of their forward propulsion, so knew what I was in for), but the boot impressed, handling everything the trail threw at it. Right out of the box, it’s comfy, puts up with a lot of wear and tear thanks to its hardy construction, and holds steady across a host of surfaces, including the slips and slides of a recent trek in the wilds of Bouddi National Park when yet another rain-bomb dumped its load. We take a long walk in search of the truth.ĭrawing inspo from its VECTIV trail-running collection, The North Face VECTIV Exploris Mid brings innovative design to the realm of the lightweight hiker. The North Face claims its new hiking boot technology boosts your stride and speed on the tracks. ![]()
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3/1/2023 0 Comments Trillian cut diamond rings![]() The shape of the Marquise cut was modified throughout the 20th century, eventually evolving into the Marquise Brilliant cut we recognise today. King Louis apparently commissioned the jeweller to design a diamond in the image of his beautiful mistress’ smile. The Marquise (meaning “French Royalty title”) first appeared in Paris in 1745 and was designed by King Louis XV’s court jeweller. This enables light to be diffused more effectively across the centre of the stone. This effect can be mitigated by making the pavilion deeper and calibrating the angles of the table and facets. The Marquise can sometimes create a “bow-tie” effect, as when light passes through the diamond it can cast a shadow across the surface of the stone, which can diminish its brilliance. These features give the Marquise a similar appearance to the hull of a small boat, which is why its shape is sometimes referred to as a “navette”, meaning “little boat” in French. Similar to the Oval cut, the Marquise is long and oval in shape, but it differs from the Oval in that it tends to be narrower with more pointed tips. A popular choice as a central stone, the Marquise is often set with pear-shaped or round side stones. The Marquise Brilliant CutĪnother cut which has the effect of elongating and flattering the finger is the elegant Marquise Brilliant cut. Kaplan was known for his ability to split a rough diamond into smaller stones with a single blow – a process known as cleaving. This was designed by the Russian diamond cutter, Lazare Kaplan, who was later recognised for his unique cut in the Jewellers International Hall of Fame. However, the first modern Oval cut appeared in the 1960s. Oval shaped diamonds have existed for more than 200 years. The Oval cut’s longer shape can also make it seem larger than differently-shaped stones with a similar weight. This is due to the Oval’s rounded, symmetrical, taller shape. Perhaps the reason this cut remains so enduringly popular is that it has the effect of elongating the finger, which can be very flattering for shorter, wider fingers, making them appear more slender. The Oval cut was an extremely popular choice as a centre stone for engagement rings as recently as 2018, and it now appears to be back in vogue yet again. The Asscher cut is also known for its “Hall of Mirrors” optical illusion effect, achieved by using diamonds with a high level of clarity to create a prism effect with maximum brilliance and lustre. It is sometimes known as a step-cut as, viewed from above, it has a step-like appearance. The Asscher cut is similar to the Emerald cut, with its square or rectangular shape, trimmed corners, deep pavilion, high crown, and broad, flat plane. This move seems to have paid off, as the cut now seems to be gaining popularity with 21st-century brides-to-be looking for vintage inspiration. For a long time, it was only possible to find original-style Asscher cut diamond rings in antique shops or through specialist Art Deco jewellers.Īt the beginning of the 21st century, the Asscher cut was redesigned, with extra facets added for a more brilliant shine. Styled in a typical Art Deco design, the cut became extremely popular for engagement rings during the 1920s, but became a rarity for decades after the style went out of vogue. The Asscher cut is named after the Dutch brothers who first designed the original cut in Amsterdam during the early 20th century. Note: The term “cut” in this article refers to the final shape of a diamond, rather than the other common-use definition of the term which describes the diamond polishing and shaping process. So, just what are the most popular diamond cuts for 2020? So, it’s really important to be aware of the different types of cuts available to you in the current marketplace. The specific type of cut – or shape – of a diamond will determine its brilliance and scintillation, as well as its overall appearance on your finger. The reason these cuts remain so popular as template designs are that they have been tried and tested over decades and centuries, and repeatedly deemed to be the best of all the possible designs out there. ![]() ![]() But when it comes to diamond cuts, most of these trends tend to be minor variations on classic, age-old designs. For example, in 2019 we saw the rise of the Pear cut, whereas it has declined in popularity in 2020. Sure, there are trends, just as in every other industry. The diamond jewellery sector is slightly different, though. The same is certainly true of the jewellery industry as a whole. The same is true for almost every other consumer industry you can think of – interior design children’s toys digital devices kitchen appliances cars etc, etc. The fashion industry is notoriously fickle when it comes to longevity. ![]() 3/1/2023 0 Comments Volumemixer windows 10![]() ![]()
3/1/2023 0 Comments Philips hotel tv volume reset![]() To do this, you need to follow the steps I described above. You need to reset the remote control and pair it again. In case you cannot pair the remote control and the TV. A message appears telling you that the pairing was successful. If you bought a new remote instead of your old one to pair it, place the remote control a short distance away from the Philips logo (about 10 cm) and press OK. The remote control is not yet paired with the TV (new remote, old TV) The remote control automatically resets and reconnects to the TV. If the pairing is successful, a message on the TV screen indicates that the remote control and the TV have successfully paired. This safeguards against the accidental pairing of the remote control and the TV (these actions can only be performed intentionally). This is where the radio receiver is located, and pairing can only occur if the signal strength is sufficient. ![]() Be sure to place the remote control next to the logo. To pair, place the remote control a short distance away from the Philips logo on the TV (about 10 cm) and press the (red) and (blue) buttons simultaneously. The remote control is already paired with another TV (used remote) Reset Philips TV remote control And you have to consider some nuances, which I’ll talk about a little later. If you bought or someone gave you a remote control that has already been paired to the TV, pairing a different remote control will be different from pairing a new one. You need to know if you want to pair another remote control with the TV. Re-pairing the remote control and Philips TV The TV can store the pairing information of up to 5 remote controls. When you turn off the power to the TV, the pairing is maintained. In this case, the remote control is paired with the TV. If you have a new Philips TV and you have turned on the TV for the first time, you are prompted to press the OK button on the remote control. After that, you cannot operate another TV with this remote control. How to pair Philips remote to TV (new TV Philips)įor the remote control to communicate with the TV, you must pair them. Also, TV Philips, very often, the communication protocol is broken, it is difficult to say what the reason is, the remote loses pairing with the TV after some time. It is not difficult, but the remote will not work with the TV if this is not done. Binding the remote control is a standard procedure. This is necessary for the TV to work properly because there might be the same TV nearby, such as in a hotel. ![]() Each remote has its identifier the TV remembers which remote it should work with. It makes no difference to the radio remote where the remote is pointed.įor the remote control to work correctly, you must create a binding between the remote and the TV. You must agree that typing on the remote and keeping it in position all the time is hard. This kind of control makes it easier to interact with the TV. The solution can be simple if you have a remote control with a keyboard, in such remote control, you can control the radio signals via Bluetooth. You should know that in most cases, it is a compatibility problem between the remote control and the TV. Why the remote control may not work properly and how to adjust the normal operation of the TV. Only turning off the power and then turning it back on after 20-30 seconds helps. The remote does not work after turning on the TV, the remote works for a few minutes and then does not respond to key presses. There are quite a few comments about problems with the Philips TV remote control, namely: Philips TV remote control does not work, problem solved Philips remote control (with keypad) does not work In most cases, 9 out of 10, this will help restore the remote and the TV to regular operation. I recommend resetting the remote control and reconnecting it to the TV to get it working again. ![]() 3/1/2023 0 Comments Obs studio icon![]() You simply select which package you would like, add it to your cart (free of charge), & checkout! Once the order is filled, you will have access to download all the stream icons in that deck! Most of them even have multiple options on color schemes, as well as light/dark variations. The categories include the following design variations: Champion style icons, Gingerbread style, Lava & Ice, Rainbow, Spooky, and Tactical. They are currently offering nine unique styles of stream deck icons (examples above) for free on their website! Visuals by Impulse is a graphic design company centered around streamers and gamers alike. ![]() They also offer a free tutorial for first time users if you happen to feel overwhelmed by the user interface they provide. The icons and tools you see above are all free to use as well as download to your computer! With the wallpaper mode you can fulfill your unique interface needs by easily transmitting ANY image across up to 15 Stream Deck keys! You can also upload your own images to use in “key” or “wallpaper mode,” making it even that much more customizable. “The only tool you’ll ever need to customize Stream Deck keys.” Obviously, if you are looking for the most fluidity when creating your new icons then why not just go straight to the source, right? Elgato has pretty much covered all the bases from an icon standpoint, with a high level of customization for them. My main reason is the level of personalization they allow you to take advantage of. These are not ranked in any particular order, however the Elgato gaming “Key Creator” seems to be the most useful on the list. “Aurora” Stream Deck Icon Pack by Nerd or Die ![]() However, it has a moderate learning curve, but once you get over it you can do wonders with this software. Using OBS Studio you can not only record directly from one source (webcam or microphone), you can easily incorporate footage from other games, add existing videos and static images, capture a portion of your screen and much more!Īll of this and much more is available completely for free. Amazing variety of available functions and options within the software.Ability to work extremely well with multiple sources,.Excellent support for multiple layers to fill up your screen,.Designed for streaming games on online services,.It’s completely free and open-source software, available for multiple platforms as well,.There are hundreds of available free extensions which you can download and use right now. ![]() You can also download a third-party extension to add some new effects and functions to this software as well. Everything you might need is here, including a picture-in-picture webcam integration, personalized watermarks support and much other “cool” things. This is one of the best free tools for streamers out there. Unlike some other apps of this kind, OBS Studio does not bother you with an in-game overlay information and does its work in the background – at your command. Even though it offers a lot of features and options, it is too much for anyone who wants to capture their own game sessions quickly and easily. This software is capable to broadcast your gaming streams to online platforms like Twitch or YouTube. ![]() 3/1/2023 0 Comments Ctla4 tcel![]() ![]() All patients’ samples were obtained with informed consent in Samsung Medical Center, Seoul, Korea, and the study was approved by the Institutional Review Board in accordance with the Declaration of Helsinki. The QIAamp DNA Mini Kit (Qiagen) and RNeasy Mini Kit (Qiagen) were used for DNA and RNA extraction, respectively. Formalin-fixed, paraffin-embedded tumor tissue was used for Sanger sequencing of 115 TCL tumor samples and targeted deep sequencing of 74 TCL tumor samples. The patients’ clinical information is summarized in Online Supplementary Table S2. The mutational status of 70 lymphoma-associated genes was analyzed using ultra-deep targeted resequencing in 74 samples of mature TCL. A functional study of the fusion gene indicated that fusion between CTLA4 and CD28 results in the activation of downstream oncogenic pathways. 10 In this study, we identified a fusion between CTLA4 and CD28 in a case of angioimmunoblastic TCL by whole transcriptome sequencing and analyzed the frequency of gene fusion in 117 cases of TCL. 6 Accordingly, controlling T-cell signaling through these two co-receptors has been a key strategy for recent cancer immunotherapies including anti-CTLA4 antibody therapy 9 8 and chimeric antigen receptor T-cell therapy utilizing the intracellular signaling domain of CD28. 7 6 Perturbing this balance can result in a number of undesirable consequences such as autoimmunity, transplant rejection, or even malignant TCL. ![]() They play critical and opposite roles in maintaining balanced T-cell signaling and, thus, the proper level of immune activation. It is, therefore, still necessary to identify additional driver mutations and dissect the interplay with T-cell signaling components.ĬTLA4 and CD28, members of the immunoglobulin superfamily that are expressed on the surfaces of T cells, are regulatory co-receptors of T-cell signaling. Furthermore, none of the mutant genes has been clearly demonstrated to be a dominant oncogenic driver. 5 1 However, the roles of these mutations in the regulation of T-cell signaling and oncogenesis have yet to be elucidated. Recent genomic studies have identified highly recurrent somatic mutations in TET2, DNMT3A, IDH2, and RHOA in diverse subtypes of mature T-cell lymphoma (TCL). Peripheral T-cell lymphoma is a malignant neoplasm of mature T cells. The CTLA4-CD28 gene fusion is likely a major contributor to the pathogenesis of T-cell lymphomas and represents a potential target for anti-CTLA4 cancer immunotherapy. The mutational landscape we obtained suggests that T-cell lymphoma results from diverse combinations of multiple gene mutations. We further investigated the mutation status of 70 lymphoma-associated genes using ultra-deep targeted resequencing for 74 mature T-cell lymphoma samples. We identified the fusion in 26 of 45 cases of angioimmunoblastic T-cell lymphomas (58%), nine of 39 peripheral T-cell lymphomas, not otherwise specified (23%), and nine of 31 extranodal NK/T cell lymphomas (29%). To estimate the frequency of this gene fusion in mature T-cell lymphomas, we examined 115 T-cell lymphoma samples of diverse subtypes using reverse transcriptase polymerase chain reaction analysis and Sanger sequencing. Ectopic expression of the fusion transcript in Jurkat and H9 cells resulted in enhanced proliferation and AKT and ERK phosphorylation, indicating activation of downstream oncogenic pathways. The fusion gene, which codes for the extracellular domain of CTLA4 and the cytoplasmic region of CD28, is likely capable of transforming inhibitory signals into stimulatory signals for T-cell activation. By RNA sequencing, we identified a fusion between the two genes from partial gene duplication in a case of angioimmunoblastic T-cell lymphoma. ![]() CTLA4 and CD28 are co-regulatory receptors with opposite roles in T-cell signaling. ![]() 3/1/2023 0 Comments Doodle car faces![]() ![]() Moreover, Cointelegraph noted that cryptocurrency bills which have introduced in the US include the Central Bank Digital Currency Study Act of 2021, the Digital Commodities Consumer Protection Act of 2022 (DCCPA), the Stablecoin Transparency Act, and the Cryptocurrency Tax Clarity Act.Īlso Read: Crypto. ![]() This actually creates more risk for customers as it puts them in a position of dealing with less regulated institutions to participate in the ecosystem,” Sherman mentioned. It is not just a beautiful design of the launch page of the search engine, they contain animation, sometimes small games are released, they can be tried directly in the browser. Popular Google Doodle Games are a kind of postcards, the release of which is timed to significant events. Each game pays tribute to key events, people, and even fictional geek culture characters. “ are reacting to an industry that is evolving constantly but overregulation could stifle that innovation poorly thought-out regulation could create a two-fold issue: first it could limit US consumers’ ability to participate in the cryptocurrency ecosystem and it could also drive these businesses to less regulated jurisdictions. Google Doodles have become part of our online culture. Redbubble brings you unique and colorful iPad cases & skins. Sherman also made the reference of Ryan Salame, co-CEO, FTX, who donated to Republicans in 2022. High quality Doodles Car inspired iPad cases & skins by independent artists and designers from around the world. It is believed that Sherman made a direct reference to Sam Bankman-Fried, former CEO, FTX, and political donations to the Democratic Party. On the basis of information by Cointelegraph, Sherman made the announcement of his plans to work with his Congress colleagues for examination of options for Federal legislation, which he expects to be executed with the financial influence of members in the cryptocurrency industry. Let us put forth every effort to retain the present car distribution clause in the new. ![]() New York officials reportedly inspecting stablecoin-oriented Paxos’ operations ![]() 3/1/2023 0 Comments Condemned 2 bloodshot pc 2018![]() ![]() Cons: Clunky fight system Load times are a pain. Condemned 2 Bloodshot PC Gameplay Xenia Canary 100 Playable Xenia Emulator Xbox 360 Emulator 2021 Updated EnjoyIf you liked the video please re. Pros: Disgusting production design that will make you head straight for the shower. Tokyo-based publisher suffers major setbacks on decline of its once-popular pachinko business game sales up overseas, but down in Japan. A former bounty hunter who finds himself on the run as part of a revamped Condemned tournament, in which convicts are forced to fight each other to the death as part of a game thats broadcast to the public. With Randy Orton, Eric Roberts, Wes Studi, Steven Michael Quezada. This is my Full Playthrough of CONDEMNED 2: BLOODSHOTPC Gameplay played from the Xenia Emulatorfrom our Live Stream.Check out the LIVE STREAM where we play A. with prices starting at 3,000 The first appearance of this product was on Amongst similar products of Sega Condemned 2: Bloodshot the cheapest. walls are barely visible, and you can do this at any time during the game in.
![]() In this tutorial, we’ll build on a sample application that was introduced in a previous article. Tutorial: IntelliJ + Telepresence = Easy Java K8s Debugging Step 1: Deploy a Sample Java Microservice Application Let’s now walk through an example of how to set all of this up. Telepresence also allows for the easy exporting of environment variables, which you can load into your local IDE or debugger. your service can connect to other remote services simply using the K8s Service names and ports. By setting up a two-way proxy between your local machine and remote Kubernetes cluster you can debug services locally as if they were running in the cluster i.e. Telepresence can be used to overcome both of these challenges. However, the challenge here is that often the environment variable configuration for your service is only available in the Kubernetes cluster. This means you can debug your copy of the service without needing to connect your debugger to the remote cluster. You can use `kubectl port-forward` to set up a local connection to a specific Pod and debug port, but you will have to re-issue the command every time the Pod name changes.Īs an alternative, you can spin up a local copy of the service under test and attempt to use `kubectl port-forward` to expose remote services (via locаlhost and their ports). You can expose the port in your Kubernetes Service YAML, but this can be a security risk if this is deployed to production, and so you typically have to maintain two copies of the YAML when using this approach. The primary issue is exposing the debug ports for your locally running IDE or debugger to connect to. Remote debugging against Java apps running in Kubernetes can be challenging. Difficulties with Debugging Java Apps Running in Kubernetes This enables you to spin up a single service or small collection of services locally and debug your apps using your existing tools while still being able to access the remote services as if you were working in the cluster. ![]() ![]() This article walks you through the use of Telepresence for seamlessly connecting your local development machine running all of your familiar debug tooling to a remote Kubernetes cluster that contains the rest of your microservices. The open source Telepresence tool can help. This then opens up the challenges of remote debugging, and the associated fiddling with debug protocols and exposing ports correctly. However, when you are working with a system that is composed of a large number of microservices running in a Kubernetes cluster, the approach you take to debugging has to change.įor one, when you want to conduct integration tests with a service you typically can’t run all of your dependent services on your local machine. A change in approach is required! Debugging Cloud Native Apps Requires a New ApproachĮasy and efficient debugging is essential to being a productive engineer. The challenge here is that many of your existing local debugging tools and practices can’t be used when everything is running in a container or on the cloud. ![]() The technologies and architectures may change when we move to the cloud, but the fact remains that we all still add the occasional bug to our code. Many Java-based organizations adopt cloud native development practices with the goal of shipping features faster. Tutorial: Learn to locally debug Java microservices with IntelliJ IDEA and Telepresence connected to a remote Kubernetes cluster This is a guest blog post by Daniel Bryant, from Telepresence ![]() 3/1/2023 0 Comments Mudrunner drywall taping tool![]() ![]() ![]() Original shipping charges are non-refundable. Drywall Hand Tools > Mudrunner Tapetech© Facebook Twitter Pinterest Google+ SKU: 14TT. Due to hygienic reasons, masks, ear plugs, and other wearables that go over the mouth and nose will not be accepted for return or exchange. Merchandise that has been worn, used, or altered will not be accepted for return or exchange. Some items can not be returned if they are opened. Returned items must have the original carton, packaging materials, and warranty information. Unless otherwise stated, Toolriver will accept merchandise in good, clean, working condition for a period of 30 days from the date-of-purchase. Toolriver is committed to your satisfaction. Physical damages, modifying, altering or using a product outside its factory parameters will void its warranty and is not covered by our standard warranty policy. * Some manufacturers may require customers to contact them directly for warranty support. For Refurbished and Clearance items this period is thirty (30) days, unless otherwise specified. Toolriver will help facilitate the return of defective product(s) to the manufacturer for repair or replacement at no cost to our customer with in the first year, unless otherwise specified. Much easier to fill and operate than a "syringe".Extended reach versus standard corner applicators.The MudRunner is the easiest angle box or corner applicator that you will ever use. Holds 50% more joint compound than a standard 8" Corner Applicator and 70% more than a 7" Corner Applicator TapeTech MudRunner MudRunner is a self contained 'no push' angle applicator that harnesses a gas charged shock absorber to squeeze out compound with a turn of the wrist.Finishes internal corners (with corner finishers). ![]() Applies compound to inside corner for tape application (with 16TT90).Applies compound to external corners for paper faced bead application (with 16TT).The Tape Tech Mud Runner holds 50% more joint compound than a standard 8" Corner Applicator and 70% more than a 7" Corner Applicator. Use it with TapeTech Corner Finishers to quickly achieve high quality, finished internal corners or with Mud Heads to apply compound to internal and external corners when installing paper-faced corner bead to drywall. Twist it back and the flow stops immediately. A simple twist of the wrist activates the piston and creates a consistent flow of joint compound. Can’t find what you’re looking for? View our full range of taping and jointing tools for perfect drywall finishing or call 01 to speak to one of our drywall tool experts.The TapeTech MudRunner® delivers joint compound to corners with precision control and minimal effort. The MudRunner® is the next generation of Corner Applicators. The TapeTech MudRunner delivers joint compound to corners with precision. We also sell spare parts for taping tools and offer a repairs service where one of our trained technicians is on hand to help you. Holds 50 more compound than a standard 8 Corner Applicator and 70 more than the 7 Applicator. Our range of products include Drywall Easy Clean Automatic Taper, Planex Long. They also come with an industry leading five-year limited warranty. The tools are easy to maintain and when looked after properly they are long lasting too. Light Industrial Tool Drywall Taping Tools TapeTech MudRunner Tube Assembly - Upgrade Your Old Tube to New Hardware & Cage, ideal for your mobile lifestyle. The TapeTech MudRunner is probably the best new tool to come out for drywall in the last 2 decades. They are designed to help you complete jobs in less time and with less effort. TapeTech Drywall Taping and Finishing Tool. 5.0 out of 5 stars1 product rating Write a. Their range of automatic taping and finishing tools are known for their excellent performance, design and engineering. TapeTech Mudrunner Drywall Corner Compound Applicator (14TT). Here at Gyproc Tools you can find automatic tapers, corner finishers, premium finishing knives and more great tools from TapeTech, all designed to help you complete jobs in less time and with less effort. Their range of automatic taping and finishing tools are known for their excellent performance, design and engineering. TapeTech has been the bestselling brand in the drywall industry for more than 30 years. ![]() |
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